| 乙酰胆碱对非洲爪蟾卵母细胞ATP-激活电流的调制作用 |
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| 引用本文： | 程剑侠,王照宇,朱凡,张玉芹.乙酰胆碱对非洲爪蟾卵母细胞ATP-激活电流的调制作用[J].武汉科技大学学报(自然科学版),2007,30(3):305-307. |
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| 作者姓名： | 程剑侠 王照宇 朱凡 张玉芹 |
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| 作者单位： | 武汉科技大学医学院,湖北,武汉,430080 |
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| 基金项目： | 湖北省自然科学基金;湖北省教育厅科研项目 |
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| 摘 要： | 研究乙酰胆碱对爪蟾卵母细胞上ATP激活电流的影响及其机理.用双电极电压钳技术记录爪蟾卵母细胞的细胞外液加入乙酰胆碱对ATP激活电流（IATP）的影响.结果显示,乙酰胆碱对大多数细胞IATP具有增强作用,而对少数细胞IATP具有抑制作用,且均呈现浓度依赖性;乙酰胆碱对IATP的调制作用是通过毒蕈碱样乙酰胆碱受体（M受体）激活实现的.
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| 关 键 词： | M受体 爪蟾卵母细胞 ATP-激活电流 双极电压钳技术 |
| 文章编号： | 1672-3090（2007）03-0305-03 |
| 修稿时间： | 2006-10-08 |
Modulation of ATP-activated current by acetylcholine in Xenopus oocytes |
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| Cheng Jianxia,Wang Zhaoyu,Zhu Fan,Zhang Yuqin.Modulation of ATP-activated current by acetylcholine in Xenopus oocytes[J].Journal of Wuhan University of Science and Technology(Natural Science Edition),2007,30(3):305-307. |
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| Authors: | Cheng Jianxia Wang Zhaoyu Zhu Fan Zhang Yuqin |
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| Institution: | Medical College, Wuhan University of Science and Technology, Wuhan 430080, China |
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| Abstract: | To investigate the modulatory effect of acetylcholine(Ach) on ATP-activated currents(IATP) of Xenopus oocytes,two electrode voltage-clamp technique is used to record the IATP in healthy Xenopus oocytes by applying Ach in extracellular fluid.The experimental result shows that in the most cells ATP-activated currents recorded are enhanced,while in a few cells they are inhibited,both of which are in a concentration-dependent manner.The modulatory effect of Ach on the IATP may be achieved by activating muscarinic receptor(M receptor). |
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| Keywords: | M receptor Xenopus oocytes ATP-activated currents two electrode voltage-clamp technique |
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