| 抗滴虫药1—（2—乙基磺酰基乙基）—2—甲基—5—硝基咪唑的合成 |
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| 引用本文： | 曹长年.抗滴虫药1—（2—乙基磺酰基乙基）—2—甲基—5—硝基咪唑的合成[J].青海大学学报,1999,17(2):21-24. |
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| 作者姓名： | 曹长年 |
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| 作者单位： | 青海大学化工学院应用化学系!西宁810016 |
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| 摘 要： | 文中报道了一种抗滴虫药物1-(2-乙基磺酰基乙基)-2-甲基-5-硝基咪唑即替硝唑,(1)]的简便合成方法。该方法以2-甲基-5-硝基味唑(5)为原料,(5)与β-羟基乙基乙硫醚(4)在酸催化下缩合生成1-(2-乙硫基乙基)-2-甲基-5-硝基味唑(6),过量的2-甲基-5-硝基咪唑可回收利用,(6)经过氧化氢氧化生成替硝唑。
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| 关 键 词： | 1-（2-乙基磺酞基乙基）-2-甲基-5-硝基咪唑 替硝唑 抗滴虫 合成 |
Synthesis of 1 - (2 - ethylsulfonylethyl) - 2 - Methyl-5-Nitroimidazole as Antitrichomonal Drug |
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| Cao Changnian.Synthesis of 1 - (2 - ethylsulfonylethyl) - 2 - Methyl-5-Nitroimidazole as Antitrichomonal Drug[J].Journal of Qinghai University(Natural Science),1999,17(2):21-24. |
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| Authors: | Cao Changnian |
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| Abstract: | 1 - (2 - ethy sulfonylethyl) - 2 - methyl - 5 - nitroimidazole tinidazole, (1) ] , as a highly potent antitrichomonal drug, has been synthesized by a facile method. Acid - catalysed condensation of 2 - methyl - 5 - nitroimidazole(5) with ethyl(2 - hydroxylethyl) sulfide(4) led to 1 - (2 - ethyl -thioethyl) - 2 - methyl - 5 - nitroimidazole(6) , and exess(5) can be recovered. (6)was oxidized to tini-dazole(1) by H2O2 in the presence of ammonium molybdenate in a good yield. |
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| Keywords: | 1 - (2 - ethylsulfonylethyl) - 2 - methyl - 5 - nitroimidaxole Tinidaxol Anti-trichomonal Synthesis |
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