| 新型结肠定位给药系统偶氮聚合物的合成与细菌降解 |
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| 引用本文： | 陈建海,陈清源,沈家瑞.新型结肠定位给药系统偶氮聚合物的合成与细菌降解[J].中山大学学报(自然科学版),2003,42(Z1):91-94. |
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| 作者姓名： | 陈建海 陈清源 沈家瑞 |
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| 作者单位： | 1. 第一军医大学附属南方医院药学部,广东,广州,510515
2. 华南理工大学材料学院,广东,广州,510640 |
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| 摘 要： | 合成与表征了用二乙基偶氮苯(DVAB)偶联的甲基丙烯酸羟乙酯(HEMA)-甲基丙烯酸甲酯(MMA)-甲基丙烯酸(MAA)偶氮共聚物,用紫外、红外、核磁共振表征该共聚物结构.结果表明共聚物中HEMA与MAA
含量对偶氮共聚物溶涨性能有很大影响.SEM、DSC、GPC测试表明,偶氮聚合物的菌解程度取决于共聚物中亲疏水成分含量.偶氮共聚物有望成为结肠靶向药物的载体.
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| 关 键 词： | 偶氮聚合物 生物降解 结肠定位给药 |
Synthesis and Bacterial Degradation of Novel Azo-polymer for Colon-specific Drug Delivery |
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| Abstract.Synthesis and Bacterial Degradation of Novel Azo-polymer for Colon-specific Drug Delivery[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2003,42(Z1):91-94. |
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| Authors: | Abstract |
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| Abstract: | Objective:To synthesize and characterize novel azo-polymers composed of 2-hydroxyethyl mathacrylate (HEMA), methyl methacrylate (MMA) and methacrylic acid (MAA) cross-linked with 4,4-divinyl azobenzene (DVAB) and to investigate the biodegradation of azo-polymer consisting of different quantities of comonomers in vitro. Methods: UV, IR 1H, 13C NMR spectra were applied to characterize the structure of copolymer.Results:The content of HEMA and MAA unit in the copolymer has a profound effect on the swelling equilibrium of azopolymer. SEM, DSC and GPC show the degree of bacterial degradation on the surface of copolymer was depended on the ratio of hydrophilic and hydrophobic unit content. Conclusion:This azopolymer could be expected to use as a colon-specific drug delivery carrier. |
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| Keywords: | azo-polymer biodegradation colon-specific drug delivery P(HEMA-MMA-MAA) |
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