Experimentelle Reversion von Tumorzellen in vivo |
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Authors: | N Peters K H Fröhlich G Bresching |
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Institution: | (1) Institut für Hydrobiologie und Fischereiwissenschaft der Universität, Olbersweg 24, D-2 Hamburg-Altona, Deutschland;(2) Anatomisches Institut der Universität Hamburg, Deutschland |
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Abstract: | Summary European eels with fast growing epidermal papillomas (cauliflower disease) were treated with quinine-sulphate. At concentrations of 15 to 60 mg/l and after 8 weeks of treatment, there occurred newly formed mucous cells and club cells in the tumor tissue. Tight contact between all cells was reestablished. The nucleus-plasma-relation had evidently decreased. Electron microscopical studies showed a restauration of degenerated cell organelles, especially of the outer membrane. Growth rate of the tumors was reduced, and at a concentration of 60 mg/l the tumor tissue ceased growing from the beginning of treatment. |
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