| 相转移催化1,2,3-苯并三唑N-烷基化的研究 |
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| 引用本文： | 张洪奎,廖联安,郭奇珍.相转移催化1,2,3-苯并三唑N-烷基化的研究[J].厦门大学学报(自然科学版),1987(3). |
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| 作者姓名： | 张洪奎 廖联安 郭奇珍 |
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| 作者单位： | 厦门大学化学系
(张洪奎，廖联安)，厦门大学化学系(郭奇珍) |
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| 摘 要： | 本文报道了在相转移催化(PTC)条件下1,2,3-苯并三唑的N-烷基化反应.合成了七个1,2,3-苯并三唑衍生物,实验结果表明:在以PEG800为相转移催化剂,K_2CO_3为硷的固-液PTC条件下,用各种不同的卤代烃为烷基化剂都得到满意的结果.1,2,3-苯并三唑的N-烷基化生成1-位和2-位取代的两种产物.我们比较了固-液和液-液两种PTC方法对生成1-位或2-位取代产物的影响;分离并测定了这些取代产物的红外光谱(IR),~1H核磁共振谱(~1HNMR)和质谱(MM);并对实验的结果进行了讨论.
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N-Alkylatfon of 1,2,3-Benzotriazole by Phase Transfer Catalysis |
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| Zhang Hongkui Liao Lianan Guo Qizhen.N-Alkylatfon of 1,2,3-Benzotriazole by Phase Transfer Catalysis[J].Journal of Xiamen University(Natural Science),1987(3). |
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| Authors: | Zhang Hongkui Liao Lianan Guo Qizhen |
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| Institution: | Department of Chemistry |
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| Abstract: | N Alkylation of 1, 2, 3 benzotriazole by phase transfer catalysis (PTC) with several alkyl halidesasalkylating agent was investigated.Seven alkylated products (a-g) were prepared. Solid-liq. PTC was compared with liq. -liq. PTC as to their effects on N-alkylation. Fair yield was obtained with PEG 800 and powdered potassium carbonate in ethyl acetate. In each case,alkylation led to mixtures of 1 and 2-substituted isomers which were separated and characterized by GC-MS, 1R and 1HNMR spectra, The corresponding data were given. The results show that the bulkier the alkylating agent, the higher the yield of 2-substituted isomer for open chain alkyl halide. The results of experiment were discussed. |
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| Keywords: | l 2 3-Benzotriazole Alkylation Phase transfer catalysis Synthesis |
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