| 聚焦超声治疗129/J小鼠外阴上皮内瘤变模型的实验研究 |
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| 引用本文： | 陈丽萍,刘毅,范秀芳,李成志.聚焦超声治疗129/J小鼠外阴上皮内瘤变模型的实验研究[J].科技导报(北京),2009,27(9). |
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| 作者姓名： | 陈丽萍 刘毅 范秀芳 李成志 |
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| 作者单位： | 重庆医科大学生物医学工程系,重庆市生物医学工程学重点实验室,重庆市超声医学工程重点实验室-省部共建国家重点实验室培育基地,重庆 400016
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| 摘 要： | 为探讨聚焦超声治疗对小鼠外阴上皮内瘤变的影响,研究治疗前后VEGF表达变化,采用苯甲酸雌二醇注入40只129/J型鼠腹部皮下,7周时建立外阴上皮内瘤变轻到中度不典型增生(Vulvar Interaepithelial Neoplasia,VIN Ⅰ～Ⅱ)小鼠模型.随机分为聚焦超声治疗组和假照组,治疗前后检测皮肤病理及VEGF表达变化.建立VIN Ⅰ～Ⅱ小鼠模型16例.结果显示聚焦超声治疗组7例皮肤基本恢复正常,VEGF表达降低.与假照组相比差异均有统计学意义(P<0.05).由此得出,聚焦超声治疗小鼠外阴内上皮瘤样病变具有无创性、安全性和有效性.
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| 关 键 词： | 外阴上皮内瘤变 聚焦超声疗法 129/J型鼠 |
Experimental Research on Focused Ultrasound Therapy for 129/J Mice Animal Model of Vulvar Interaepithelial Neoplasia |
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| CHEN Liping,LIU Yi,FAN Xiufang,LI Chengzhi.Experimental Research on Focused Ultrasound Therapy for 129/J Mice Animal Model of Vulvar Interaepithelial Neoplasia[J].Science & Technology Review,2009,27(9). |
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| Authors: | CHEN Liping LIU Yi FAN Xiufang LI Chengzhi |
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| Institution: | CHEN Liping,LIU Yi,FAN Xiufang,LI Chengzhi Department of Biomedical Engineering of Chongqing Medical University,Key Laboratory of Biomedical Engineering of Chongqing,State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing , MOST,Chongqing 400016,China |
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| Abstract: | |
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| Keywords: | vulvar intraepithelial neoplasia focused ultrasonic therapy 129/J mouse |
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