The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain |
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Authors: | P. L. Lantos |
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Affiliation: | (1) Department of Neurological Studies and Bland-Sutton Institute of Pathology, Middlesex Hospital Medical School, W1P 8AA London, (England) |
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Abstract: | ![]() Summary The fine structure of early cell proliferations induced transplacentally by ethylnitrosourea in the rat brain reveals that the cells show features of the undifferentiated cells of the subependymal plate: high nuclear-cytoplasmic ratio, scarcity of cell organelles and dominance of free over membrane-bound ribosomes. These findings suggest that most, if not all, gliomas induced by ethylnitrosourea originate from these primitive cells.Acknowledgments. I thank D. J. Cox and G. J. Pilkington for their skilful technical assistance. |
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