| 实验性交感性眼炎发病机制的研究 |
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| 引用本文： | 杨清导,姚大卫,C.Y.W.Au. 实验性交感性眼炎发病机制的研究[J]. 暨南大学学报(自然科学与医学版), 1988, 0(4) |
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| 作者姓名： | 杨清导 姚大卫 C.Y.W.Au |
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| 作者单位： | 暨南大学医学院，香港中文大学医学院，香港中文大学医学院 |
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| 基金项目： | 由京港学术交流中心资助 |
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| 摘 要： | 以13只白色豚鼠作实验,其中3只为 C 组作对照,另10只分为 A、B 二个组,在以牛晶体蛋白连续皮内注射4次致敏之后,做一只眼的晶体截囊术。术后 A 组皮下注射生理盐水,B 组则皮下注射环孢霉素(Cyclosporine)。结果 A 组发生交感性眼炎,而 B 组和 C 组均未发生。因为环孢霉素具有选择性的抑制 T 淋巴细胞的功能,故推测交感性眼炎的发病机制可能与 T 淋巴细胞的关系极为密切。
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| 关 键 词： | 豚鼠 牛晶体蛋白 截囊术 环孢霉素 交感性眼炎 |
A Study on Pathogenesis of Experimental Sympathetic Ophthalmia |
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| Yang Qingdao. A Study on Pathogenesis of Experimental Sympathetic Ophthalmia[J]. Journal of Jinan University(Natural Science & Medicine Edition), 1988, 0(4) |
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| Authors: | Yang Qingdao |
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| Affiliation: | Yang Qingdao (JNUMC) D.T.Yew C.Y.W.Au (Medical College of 1he Chinese University of Hong Kong) |
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| Abstract: | 13 Alhino guinea pigs were experimented upon.5 animals each for GroupsA, B,and 3 for Group C,group A and B were immunized by bovine lens protein. The lenses were disrupted afterwards,then group A animals were injected subeutaneously with normal saline and group B with eyclosporine.The results was that group A developed sympathetic ophthalmia,group B and grouP C could not develop sympathetic ophthalmia.As cyclosporine is a selective suppressive drug to T lymphoeyte the authors suppose that the pathogenesis of sympathetic ophthalmia is closely related to T lymphocyte. |
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| Keywords: | Guinea pig Bovine lens protein Lens disrupt Cyclosporine Sympathetic ophthalmia |
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