Variation in complement factor 3 is associated with risk of age-related macular degeneration |
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| Authors: | Maller Julian B Fagerness Jesen A Reynolds Robyn C Neale Benjamin M Daly Mark J Seddon Johanna M |
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| Institution: | Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. |
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| Abstract: | The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample. |
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