Crossing paths: interactions between the cell death machinery and growth factor survival signals |
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Authors: | Gabriela Brumatti Marika Salmanidis Paul G Ekert |
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Institution: | (1) Children’s Cancer Centre, Murdoch Children’s Research Institute, Royal Children’s Hospital, Department of Paediatrics, University of Melbourne, Flemington Rd Parkville, Melbourne, 3052, Australia |
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Abstract: | Cytokines and growth factors play a crucial role in the maintenance of haematopoietic homeostasis. They transduce signals
that regulate the competing commitments of haematopoietic stem cells, quiescence or proliferation, retention of stem cell
pluripotency or differentiation, and survival or demise. When the balance between these commitments and the requirements of
the organisms is disturbed, particularly when it favours survival and proliferation, cancer may result. Cell death provoked
by loss of growth factor signalling is regulated by the Bcl-2 family of apoptosis regulators, and thus survival messages transduced
by growth factors must regulate the activity of these proteins. Many aspects of direct interactions between cytokine signalling
and regulation of apoptosis remain elusive. In this review, we explore the mechanisms by which cytokines, in particular Interleukin-3
and granulocyte–macrophage colony-stimulating factor, promote cell survival and suppress apoptosis as models of how cytokine
signalling and apoptotic pathways intersect. |
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Keywords: | |
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