| 人原发性骨肉瘤移植瘤的超微结构和碱性磷酸酶的定位研究 |
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| 引用本文： | 曹汉民,华燕,蒋知节,谢雄.人原发性骨肉瘤移植瘤的超微结构和碱性磷酸酶的定位研究[J].华东师范大学学报(自然科学版),1991(2). |
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| 作者姓名： | 曹汉民 华燕 蒋知节 谢雄 |
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| 作者单位： | 华东师范大学生物学系
(曹汉民，华燕)，上海第一医科大学附属华山医院
(蒋知节)，上海第一医科大学附属华山医院(谢雄) |
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| 摘 要： | 用透射电镜观察人原发性骨肉瘤及其移植瘤的超微结构及碱性磷酸酶的活性变化,实验结果发现第1至第7代移植瘤的超微结构和碱性磷酸酶活性与对照组原发瘤一致;第9代以后的移植瘤的碱性磷酸酶含量明显减少,而细胞超微结构仍具有原发瘤细胞的一些特点,因而证明在本实验条件下,第1至第7代移植瘤可以作为骨肉瘤生物学特性和进一步实验治疗研究的良好材料.
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| 关 键 词： | 骨肉瘤 移植瘤 超微结构 碱性磷酸酶 |
Ultrastructural Observation and Localization of Akline Phosphatase on Human Osteosarcoma Serially Transplanted into Nude Mice |
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| CAO HANMIN, HUA YAN.Ultrastructural Observation and Localization of Akline Phosphatase on Human Osteosarcoma Serially Transplanted into Nude Mice[J].Journal of East China Normal University(Natural Science),1991(2). |
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| Authors: | CAO HANMIN HUA YAN |
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| Abstract: | Ultrastructure and actived change of akline phosphatase on human steosarcoma and xenotropic are studied.Ultrastructure and activation of akline phosphatase on xenotropic from first to seventh generations are similar to that before transplantation; Akline phosphatases on xenotripic from ninth to seventeenth generations decrease considerally.However, ultrastrueture of tumorous cells continues to have some properties of original osteosarcoma.These observations suggest that the xenotropic from first to seventh generations is a rare experimental model for studing mechanism of disease and cure. |
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| Keywords: | osteosarcoma xenotropic ultrastructure akline phosphatase |
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