Effect of vincristine on glucose-induced insulin secretion in man

Summary 60 min after the injection of therapeutic doses of vincristine for cancer chemotherapy, there is a reduction of the total (40%) and of the acute phase (43%) areas of insulin secretion induced by a 5-g i.v. glucose load, and the constant of glucose utilization is reduced by 25%. No differences are observed after 3 5-g i.v. glucose loads given at hourly intervals in control subjects.Acknowledgment. The authors are grateful to Mr S. Castiglioni and to Miss Maria Luisa Fuser for their skillful technical assistance.