Nibbling within the nucleus: turnover of nuclear contents |
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Authors: | D Mijaljica M Prescott R J Devenish |
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Institution: | (1) Department of Biochemistry and Molecular Biology, and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton campus, Victoria, 3800, Australia |
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Abstract: | As the site of gene expression and regulation, the nucleus is the control center of the cell. It might be thought that degradation
of nuclear contents is strictly ‘off-limits,’ given the importance of the genetic information contained within the nucleus,
but it has recently been reported that partial degradation of the nucleus may occur in yeast. Here we summarize the evidence
for the degradation and quality control of proteins found with the nucleus and its compartments, and of nucleic acids that
may occur under certain specific conditions. Only under certain special conditions such as differentiation of the lens are
the entire nuclear contents degraded.
Received 6 September 2006; received after revision 25 October 2006; accepted 13 December 2006 |
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Keywords: | Autophagy degradation exosome nucleoporin nuclear compartment nucleus piecemeal microautophagy protein quality control |
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