基于格兰杰因果关系的磁刺激内关穴脑功能网络的研究

磁刺激具有有效、无痛、无损伤、易于重复和操作简便等显著的优点,在中枢神经功能检测和神经功能恢复等方面具有广泛的应用价值.穴位是中医针灸调控神经系统由体表刺激到体内的切入点,对研究大脑调控机制和疾病的治疗有重要意义.本研究利用格兰杰因果关系构建基于磁刺激内关穴（PC6）的脑电（EEG）信号的脑功能网络,探究大脑的因果关系变化规律,并对比分析了安静和磁刺激两种状态下的脑功能网络的拓扑性质.研究表明,磁刺激内关穴前整个大脑系统的信息流向是平衡的,而磁刺激内关穴后额叶区的格兰杰因果关系的强度增加,且信息流向主要由额叶流向枕叶.顶叶区C4介数中心性强度显著提高.网络的传输效率提高,网络的"小世界"属性增强.

Study of Brain Functional Network Based on Granger Causality of EEG Under Magnetic Stimulation at Acupuncture Point

Magnetic stimulation has the significant advantages of effective,painless,non-invasive,easy to duplicate and simple operationin the application of central nerve function test and nerve function recovery.Acupoint is the breakthrough point between body surface stimulation and internal nervous system regulation,which is significant in the study of regulatory mechanism of t he brain complex dynamic system and rehabilitation treatment of some diseases.In this paper, Granger causality was used for brain functional network building based on EEG signal under magnetic stimulation at PC6 acupoint,explored the change rule of the causation of the brain during the stimulation.In addition,the features of complex network were comparatively analyzed between the quiescent and stimulated states.Our experimental results show the information flow of the brain system at the quiescent state is balanced.The power of the GC was increased,the flow of information was mainly from the frontal lobe to the occipital lobe,the central intensity of C4 in parietal lobe was significantly increased,the efficiency of information transmission was improved and the "small-world" property was stronger through stimulating PC6 acupoint.