Visceral localization of 14C gentamicin in the rat after administration of a single dose

When administered intravenously to Rats, 14C Gentamicin decreased very fast in all tissues, except in kidney and cartilage. Some flexures of the small intestine contained radioactive carbon, and that was evidence for the biliary elimination of a part of the aminoglycoside. In animals with water restriction, the distribution of the antibiotic in tissues was similar to the distribution in animals with free access to water.