Influence of substance P and fragments on passive avoidance behavior |
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Authors: | O Gaffori J M Stewart D de Wied |
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Institution: | (1) Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, NL-3521 GD Utrecht, (The Netherlands);(2) Health Sciences Center, University of Colorado, Denver, Colorado, USA;(3) Present address: Health Sciences Center, Denver, Colorado, USA |
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Abstract: | Summary N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11)) and the c-terminal, fragment pyroglutamyl-SP-(7-11) attenuated passive avoidance behavior when picogram amounts were injected into the nucleus accumbens. In contrast, the N-terminal fragment, SP-(1-7) had an opposite effect and facilitated passive avoidance behavior. |
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