| 基于TCMSP抗肿瘤中药小分子EGFR-TKI的研究 |
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| 引用本文： | 刘志强,王博龙. 基于TCMSP抗肿瘤中药小分子EGFR-TKI的研究[J]. 井冈山大学学报(自然科学版), 2018, 0(2): 87-92 |
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| 作者姓名： | 刘志强 王博龙 |
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| 作者单位： | 宜春学院化学与生物工程学院 |
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| 基金项目： | 江西省教育厅科技计划项目（GJJ12596） |
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| 摘 要： | 目的研究分析中药小分子表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)的抗肿瘤情况。方法挖掘中药系统药理学数据库与分析平台(TCMSP)中药小分子表皮生长因子受体抑制剂,利用反向分子对接服务器(DRAR-CPI)进行靶点验证。结果木犀草素、槲皮素、金雀异黄酮、表没食子儿茶素没食子酸酯、漆黄素5种中药小分子与表皮生长因子受体(EGFR)结合良好。结论中药小分子EGFR-TKI能从多个靶点、多种途径抑制肿瘤细胞的生长和扩散,利用中药小分子开发新一代多靶点EGFR-TKI具有广阔的前景。
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| 关 键 词： | 中药小分子 肿瘤 表皮生长因子受体 反向分子对接 靶点 |
| 收稿时间： | 2018-01-07 |
| 修稿时间： | 2018-02-12 |
ANTI-TUMOR SMALL MOLECULE EGFR-TKI FROM CHINESE MEDICINE BASED ON TCMSP |
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| LIU Zhi-qiang and WANG Bo-long. ANTI-TUMOR SMALL MOLECULE EGFR-TKI FROM CHINESE MEDICINE BASED ON TCMSP[J]. Journal of Jinggangshan University(Natural Sciences Edition), 2018, 0(2): 87-92 |
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| Authors: | LIU Zhi-qiang and WANG Bo-long |
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| Affiliation: | School of Chemical and Biological Engineering, Yichun University, Yichun, Jiangxi 336000, China and School of Chemical and Biological Engineering, Yichun University, Yichun, Jiangxi 336000, China |
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| Abstract: | Objective:To study the status of the anti-tumor small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) from Chinese medicine. Methods:We collected the Chinese medicine small molecule EGFR-TKI based on traditional Chinese medicine pharmacology system technology platform (TCMSP), and predicted their targets using reverse molecular docking server (DRAR-CPI). Results:Luteolin, quercetin, genistein, epigallocatechin-3-gallate, fisetin could interact with the EGFR well. Conclusion:Chinese medicine small molecule EGFR-TKI could inhibit the growth and proliferation of tumor cell by multiple targets and approaches. It has a broad prospect using traditional Chinese medicine small molecules to develop a new generation of multiple targets EGFR-TKI. |
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| Keywords: | small molecules of traditional Chinese medicine tumor epidermal growth factor receptor reverse molecular docking targets |
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