| 西北寒燥证证候动物模型的生物学基础研究 |
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| 引用本文： | 高振,阿地力江·阿布力米提,胡汉华,哈木拉提·吾甫尔.西北寒燥证证候动物模型的生物学基础研究[J].科技导报(北京),2009,27(2). |
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| 作者姓名： | 高振 阿地力江·阿布力米提 胡汉华 哈木拉提·吾甫尔 |
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| 作者单位： | 高振,GAO zhen(新疆医科大学中医学院,乌鲁木齐,830054);阿地力江·阿布力米提,哈木拉提·吾甫尔,ABULIMITI Adilijiang,UPER Hamurat(新疆医科大学维吾尔医药系,乌鲁木齐,830054);胡汉华,Hu Hanhua(新疆医科大学基础医学院,乌鲁木齐,830054)
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| 摘 要： | 为揭示西北干燥寒冷环境对机体产生影响的生物学基础,选用ICR小鼠,根据中医病因学说理论,用人工气候箱模拟新疆这种特有的干燥寒冷环境,并作用于小鼠,建立寒燥证证候模型,以正常喂养为空白对照组.试验处理第21天后,用摘眼球取血法和解剖法分别取出小鼠的血液和各种脏器,在HE染色光镜下观察其组织病理学改变.用透射电镜观察其细胞超微结构的改变,并用高效液相色谱-电化学检测法测定小鼠脑组织和外周血中单胺类神经递质的变化.和空白对照组相比,组织形态学方面的改变主要是中心血管的轻度扩张和淋巴细胞增多;超微结构方面主要以水肿表现为主;单胺类神经递质方面,外周血中的去甲肾上腺素(NE)、多巴胺(DA)明显低于对照组(P＜0.01),5-羟色胺(5-HT)高于对照组(P＜0.05),而脑中去甲肾上腺素、多巴胺和5-羟色胺含量均显著高于对照组(P＜0.01).寒燥环境可导致小鼠体内"寒燥之气"的产生,由此推论寒燥环境是西北寒燥证形成的主要原因;且西北寒燥证不是机体某一脏器的改变,而是整体性、全身性、系统性的改变.
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| 关 键 词： | 寒燥环境 组织形态学 超微结构 单胺类神经递质 西北寒燥证 |
Biological Basis of Northwest Dry and Cold Syndrome |
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| GAO Zhen,ABULIMITI Adilijiang,HU Hanhua,UPER Hamurat . Traditional ChineseMedicine School,Xinjiang Medical University,Ulumuqi ,China . Faculty of Traditional Uighur,China . School of Basic Medicine,China.Biological Basis of Northwest Dry and Cold Syndrome[J].Science & Technology Review,2009,27(2). |
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| Authors: | GAO Zhen ABULIMITI Adilijiang HU Hanhua UPER Hamurat Traditional ChineseMedicine School Xinjiang Medical University Ulumuqi China Faculty of Traditional Uighur China School of Basic Medicine China |
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| Institution: | GAO Zhen1,ABULIMITI Adilijiang2,HU Hanhua3,UPER Hamurat2 1. Traditional ChineseMedicine School,Xinjiang Medical University,Ulumuqi 830054,China 2. Faculty of Traditional Uighur,China 3. School of Basic Medicine,China |
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| Abstract: | In order to study the effects on biological bodies of a dry and cold environment, several male ICR mice were put under a dry and cold condition to simulate Xinjiang's unique dry and cold environment, to establish a mice model of northwest dry and cold syndrome for the first time in China based on the theory of traditional Chinese medicine. After 21 days, the animals organs were taken out in order to observe histological changes by optical microscopy, and to observe ultra -structural changes by electron micr... |
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| Keywords: | dry and cold environment histomorphology ultrastructural monoamine neurotransmitters northwest syndrome |
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