Die Beeinflussung der Leukozytenphagozytose mit Phlorrhizin

Summary In the rat the intraperitoneally administered phlorrhizin significantly reduces the phagocytosis of bacteria by leucocytes, as determined by thePlatonow-Ludány-Vajda method, with the mean decrease being — 33.5%. The effect is reversible. The phenomenon appears to be due to an alteration of carbohydrate metabolism in the leucocytes. The experiments supply new evidence supporting the view that alongside biophysical factors (surface effects) also cellular metabolic processes may play important roles in the phagocytotic activity of leucocytes.