| 化学物质对自由生活线虫毒性效应生物标志物研究进展 |
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| 引用本文： | 王硕治,汝少国,杜恩在.化学物质对自由生活线虫毒性效应生物标志物研究进展[J].科技导报(北京),2007,25(18):75-80. |
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| 作者姓名： | 王硕治 汝少国 杜恩在 |
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| 作者单位： | 中国海洋大学海洋生命学院 山东青岛266003 |
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| 基金项目： | 国家自然科学基金资助项目(30671618) |
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| 摘 要： | 自由生活线虫在环境中分布广泛,是理想的毒理学研究模型动物。目前,以秀丽隐杆线虫(Caenorhabditiselegans)为代表的模型动物已得到广泛应用,并筛选出大量用于毒理学研究的生物标志物。本文综述了自由生活线虫作为生物标志物模型动物的优势,以及应用于环境毒理学的行为、生理、生化生物标志物的研究进展,并展望了未来发展趋势和研究方向。
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| 关 键 词： | 自由生活线虫 秀丽隐杆线虫 环境毒理学 生物标志物 |
| 文章编号： | 1000-7857（2007）18-0075-06 |
| 修稿时间： | 2007-08-10 |
Effects of Environmental Chemicals on Biomarkers Using Free-living Nematode |
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| WANG Shuozhi,RU Shaoguo,DU Enzai.Effects of Environmental Chemicals on Biomarkers Using Free-living Nematode[J].Science & Technology Review,2007,25(18):75-80. |
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| Authors: | WANG Shuozhi RU Shaoguo DU Enzai |
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| Institution: | College of Marine Life Sciences, Ocean University of China, Qingdao 266003, Shangdong Province, China |
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| Abstract: | The free-living nematode, which could be found in a very wide environment, is an ideal and efficient model for testing the effects of xenobiotic chemicals in vivo. Many effective biomarkers were detected in Caenorhabditis elegans, as a commonly used laboratory model by environmental toxicologists. Currently applied biomarkers of nematode are introduced in this paper, the advantages of nematode bioassay and the future prospects are discussed. |
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| Keywords: | free-living nematode Caenorhabditis elegans environmental toxicology biomarker |
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