| 细胞色素P450酶生物转化及新催化反应的最新进展 |
| |
| 引用本文： | 潘丽霞,朱婧,王青艳,杨登峰.细胞色素P450酶生物转化及新催化反应的最新进展[J].广西科学,2018,25(3):258-261. |
| |
| 作者姓名： | 潘丽霞 朱婧 王青艳 杨登峰 |
| |
| 作者单位： | 广西科学院非粮生物质酶解国家重点实验室国家非粮生物质能源工程技术研究中心广西生物质产业化工程院广西生物炼制重点实验室;广西科学院广西北部湾海洋研究中心广西海洋天然产物与组合合成生物化学重点实验室 |
| |
| 基金项目： | 国家自然科学基金项目(31660251)和广西自然科学基金项目(2017GXNSFAA198010)资助 |
| |
| 摘 要： | 细胞色素P450酶(P450s或CYPs)是一类广泛存在于生命体中,依赖于亚铁血红素催化多种底物的单加氧酶。一方面,它涉及许多高活性天然产物生物合成的关键步骤,对其生物转化研究有助于提高活性分子的产率和活性;另一方面,其催化涉及金属元素以及辅助因子,其蛋白质改造和新催化反应的研发也不断取得新突破。本文就细胞色素P450酶这两方面的最近研究进展进行了总结与论述。
|
| 关 键 词： | 酶工程 细胞色素P450酶 生物转化 新催化反应 |
| 收稿时间： | 2018/4/24 0:00:00 |
The Latest Advance of Biotransformation and New Catalytic Reaction of Cytochrome P450 Enzymes |
| |
| PAN Lixi,ZHU Jing,WANG Qingyan and YANG Dengfeng.The Latest Advance of Biotransformation and New Catalytic Reaction of Cytochrome P450 Enzymes[J].Guangxi Sciences,2018,25(3):258-261. |
| |
| Authors: | PAN Lixi ZHU Jing WANG Qingyan and YANG Dengfeng |
| |
| Institution: | State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center of Non-food Biorefinery, Guangxi Biomass Industrialization Engineering Institute, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China,State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center of Non-food Biorefinery, Guangxi Biomass Industrialization Engineering Institute, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China,State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center of Non-food Biorefinery, Guangxi Biomass Industrialization Engineering Institute, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China and Guangxi Beibu Gulf Marine Research Center, Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China |
| |
| Abstract: | Cytochrome P450 enzymes (P450s or CYPs) are a widespread large super family of mono-oxygenase that catalyzes the different substrates via heme in life beings.On the one hand, P450s involves in the key step of high-active natural product biosynthetic pathway, its biotransformation studies will help to increase the yield and activity of active molecules.On the other hand, its catalysis involves in metal elements and cofactors, new breakthroughs have been made in the protein modification and new catalytic reaction of P450s.In this article the latest advances in these two aspects of cytochrome P450 enzymes have been summarized and discussed. |
| |
| Keywords: | enzyme engineering cytochrome P450 enzymes biotransformation new catalytic reaction |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《广西科学》浏览原始摘要信息 |
| 点击此处可从《广西科学》下载免费的PDF全文 |
|
