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| 川楝素抗肿瘤作用机制研究进展 | |
| 引用本文： | 王小娟.川楝素抗肿瘤作用机制研究进展[J].科学技术与工程,2011,11(2):281-285. |
| 作者姓名： | 王小娟 |
| 作者单位： | 1. 安徽医科大学药理学教研室,合肥,230032;军事医学科学院放射与辐射医学研究所,北京,100850 2. 沈阳药科大学制药工程学院,沈阳,110016 3. 军事医学科学院放射与辐射医学研究所,北京,100850 4. 安徽医科大学药理学教研室,合肥,230032 |
| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目） |
| 摘 要： | 川楝素(toosendanin)是从楝属植物的根茎及川楝果实(川楝子)中提取的一种三萜化合物。经研究证明其通过影响K+、Ca2+通道活性作用于神经系统、呼吸系统、神经肌肉接头及消化系统。近年来研究证明其通过诱导细胞分化及凋亡从而具有抗肿瘤作用,本文综述了川楝素的抗肿瘤作用及机制,为临床开发应用提供参考。 |
| 关 键 词： | 川楝素 抗肿瘤 细胞色素c 机制 细胞凋亡 |
| 收稿时间： | 2010/10/25 0:00:00 |
| 修稿时间： | 2010/10/25 0:00:00 |
Review on anti-tumor effects and mechanisms of toosendanin |
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| wang xiaojuan.Review on anti-tumor effects and mechanisms of toosendanin[J].Science Technology and Engineering,2011,11(2):281-285. | |
| Authors: | wang xiaojuan |
| Institution: | 2 (Department of Pharmacology,Anhui Medical University1,Hefei 230032,P.R.China;Institute of Radiation Medicine,Academy of Military Medical Sciences2,Beijing 100850,P.R.China;School of Pharmccology Engineering,Shenyang Pharmary University3,Shenyang 110016,P.R.China) |
| Abstract: | Abstract: Toosendanin, a triterpenoid extracted from the root ,stalk and fruit of Melia toosendan Sieb et Zucc. It had found that toosendanin could influence the activity of K channels and Ca2 channels, then effected the nervous system, respiratory system, neuromuscular junction and digestive system. Recent researches report that toosendanin plays an important role in anti-tumor by induce cancer cells differentiation and apoptosis. This article demonstrates the effects and mechanisms of toosendanin on cancer cells, in order to provide some evidences for fundamental research and further study. |
| Keywords: | toosendanin anti-tumor cytochrome c mechanism apoptosis |
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