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| 朊病毒和朊病毒疾病治疗的研究进展 | |
| 引用本文： | 何冬兰. 朊病毒和朊病毒疾病治疗的研究进展[J]. 中南民族大学学报(自然科学版), 2003, 22(3): 27-31 |
| 作者姓名： | 何冬兰 |
| 作者单位： | 中南民族大学化学与生命科学学院 |
| 基金项目： | 国家民委科研基金项目 ( MZY0 2 0 0 2 ) |
| 摘 要： | 介绍了朊病毒的基本特征、化学结构以及可能具有的生理功能：参与神经系统功能的维持；通过抗氧化途径而保护神经系统细胞免受氧化损伤；参与淋巴细胞的信号转导；参与核酸代谢，给出了朊病毒治疗的几种方法，并分析了这些方法的利弊，提出了朊病毒研究拟待解决的9个问题。 |
| 关 键 词： | 朊病毒 海绵状脑病 正常朊病毒 致病性朊病毒 治疗 |
| 文章编号： | 1672-4321(2003)03-0027-05 |
| 修稿时间： | 2003-01-26 |
Research Progress on Prion and Prion Disease Therapy |
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| He Donglan He Donglan Assoc Prof,College of Chemical and Life Science,SCUFN,Wuhan ,China. Research Progress on Prion and Prion Disease Therapy[J]. Journal of South-Central Univ for, 2003, 22(3): 27-31 | |
| Authors: | He Donglan He Donglan Assoc Prof College of Chemical Life Science SCUFN Wuhan China |
| Affiliation: | He Donglan He Donglan Assoc Prof,College of Chemical and Life Science,SCUFN,Wuhan 430074,China |
| Abstract: | This paper reviews the basic feature,chemical structure of prion protein and prion disease,plausible physical functions of PrPc. PrPc may be associated with keeping the function of nervous system and protect neuron from oxidative stress by its antioxidant function; It probably take part in signal transduction and the metabolism of nucleic acid in neuronal cell. Several strategies for the development of rational therapeutics, their advantages and their disadvantages were introduced.Nine kinds of questions will be studied in the near future. |
| Keywords: | prion spongiform encephalopathy PrPc PrPsc therapy |
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