Regulation of the retinal interphotoreceptor matrix Na by the retinal pigment epithelium during the light response |
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Authors: | S. Hodson I. Armstrong C. Wigham |
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Affiliation: | (1) Department of Optometry and Vision Sciences, UWC Cardiff, P.O. Box 905, CF1 3XF Cardiff, UK |
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Abstract: | We examined the rabbit retinal pigment epithelium (RPE) for Na transport properties which would allow it to buffer undesirable changes in Na concentrations in the interphotoreceptor matrix (IPM) during light and dark cycles. The RPE is selectivity permeable to sodium. Open and short circuit transport studies with RPE indicate a circulating (choroid to retina and back) Na current which does not compromise the electrical integrity of the blood brain barrier but together with the Na permeselectivity is of sufficient magnitude to buffer both upwards and downwards movements of IPM [Na] during light or dark responses. |
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Keywords: | Retinal pigment epithelium sodium light response retina |
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