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Comparison of diurnal and nocturnal rates of 5-hydroxytryptamine turnover in the rat mediobasal hypothalamus
Authors:T S King  S Steinlechner  R W Steger
Institution:(1) Departments of Cellular and Structural Biology and Obstetrics-Gynecology, The University of Texas Health Science Center, 78284 San Antonio, Texas, USA;(2) Fachbereich Biologie der Philipps-Universität, Zoologie, D-3550 Marburg, (Federal Republic of Germany)
Abstract:Summary Rates of 5-hydroxytryptamine (5-HT) turnover in the mediobasal hypothalamus of male rats were estimated using pharmacological methods during the daytime and at night. Concentrations of 5-HT in this hypothalamic area were higher nocturnally than diurnally; this was apparently due to increased 5-HT synthesis and decreased 5-HT catabolism at night.Supported by NIH grant RR07187 (TSK) and NIH grant HD10202 (Neuroendocrine Core).
Keywords:Rat hypothalamus  hypothalamus  rat  5-hydroxytryptamine turnover  diurnal  5-hydroxytryptamine turnover  nocturnal
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