| 稀土丙二酸类配合物的合成和体外抗癌活性的初步研究 |
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| 引用本文： | 吴振,高国辉.稀土丙二酸类配合物的合成和体外抗癌活性的初步研究[J].黑龙江大学自然科学学报,2003,20(4):104-107. |
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| 作者姓名： | 吴振 高国辉 |
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| 作者单位： | 黑龙江大学,化学化工学院,黑龙江,哈尔滨,150080 |
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| 摘 要： | 合成了七个稀土丙二酸类配合物(RE2(C3H2O4)3,RE=Sm,Eu,Gd,Dy,Nd)、1,1-环丁烷二羧酸铕(Eu2(C6H6O4)3)和1,1-环戊烷二羧酸铕(Eu2(C2H8O4)3),其中1,1-环丁烷二羧酸铕和1,1-环戊烷二羧酸铕稀土配合物为首次报导。经元素分析、红外光谱、热分析确证了它们的组成为RE2A3·nH2O(n=6,3,2)。体外抗肿瘤活性实验表明有一定的细胞毒活性。
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| 关 键 词： | 稀土配合物 抗癌活性 丙二酸稀土 1 1-环丁二羧酸铕 1 1-环戊二羧酸铕 |
| 文章编号： | 1001-7011(2003)04-0104-04 |
| 修稿时间： | 2003年6月24日 |
Synthesis of complexes of rare earth and malonic acid and studies of anti-tumor activity in vitro |
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| WU Zhen,GAO Guo-hui.Synthesis of complexes of rare earth and malonic acid and studies of anti-tumor activity in vitro[J].Journal of Natural Science of Heilongjiang University,2003,20(4):104-107. |
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| Authors: | WU Zhen GAO Guo-hui |
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| Abstract: | Seven complexes of rare earth and malonic RE2 (C3H2O4) 3, RE = Sm, Eu, Gd, Dy, Nd], cyclobutane-1, 1 - dicarboxylic acid, cyclopentane- 1,1 - dicarboxylic acid are prepared, and it is first reported that complexes of Europium and cyclobutane - 1, 1 - dicarboxylic acid, cyclopentane-1, 1-dicarboxylic acid have been synthesized. The complexes are confirmed by element analysis and IR. The results show that the complexes have cytotoxicity on HeLa cells for 48 h in vitro. |
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| Keywords: | rare earth complex anti- tumor acitivity cyclobutane- 1 1 -dicarboxylic acid Europium cyclopentane- 1 1 - dicarboxylic acid Europium |
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