Transgenic and knock-out mice for deciphering the roles of EGFR ligands |
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Authors: | Wong R W C |
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Institution: | (1) Department of Anatomy and Cell Biology, Graduate School of Medicine, University of Tokyo, Tokyo 113–0033 (Japan), Fax 81-3-5689-4856, e-mail: richard@m.u-tokyo.ac.jp, JP |
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Abstract: | Generation of genetically engineered mice with either gain-of-function or loss-of-function mutations is the most popular
technique for determining gene functions and the interrelationship between molecules in vivo. These models have provided a
wealth of information about the developmental and physiological roles of oncogenes and growth factors. To date, transgenic
techniques have been used extensively to study the functions of the epidermal growth factor (EGF) family. This review highlights
some of the major recent findings pertinent to the EGF receptor (EGFR) and its ligands with special reference to elucidating
how EGF and its related growth factors work together to regulate reproduction, growth and development. Finally, future investigations
on ligand-ligand communications, EGFR and its ligands in neural stem cell research, and the mechanisms of EGFR signaling and
trafficking in cells are also suggested.
Received 24 May 2002; received after revision 15 July 2002; accepted 16 July 2002 |
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Keywords: | , EGF, EGFR, knock-out, transgenic, stem cell, growth factor, motor protein, transport, |
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