| 对羟基苯乙酸的合成 |
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| 引用本文： | 李胜辉,夏菁,张立龙,王尧轩.对羟基苯乙酸的合成[J].河北大学学报(自然科学版),2012,32(3):265-268. |
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| 作者姓名： | 李胜辉 夏菁 张立龙 王尧轩 |
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| 作者单位： | 河北大学化学与环境科学学院,河北保定,071002 |
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| 基金项目： | 河北省自然科学基金-石药集团医药联合研究基金资助项目，河北大学实验室开放基金资助项目 |
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| 摘 要： | 以乙醛酸和苯酚为起始原料,在碱性溶液中经缩合反应得到对羟基扁桃酸钠,进一步经亚硫酸氢钠还原得到对羟基苯乙酸.目标产物经液相色谱进行了鉴定,结果表明,对羟基苯乙酸质量分数97.5%,纯度99.65%.研究发现:缩合反应中乙醛酸∶苯酚∶氢氧化钠的物质的量的比为1∶1.5∶2.5时,对羟基扁桃酸钠的收率可达85%;还原反应优化工艺:n(对羟基扁桃酸钠)∶n(亚硫酸氢钠)=1∶1.1,反应温度100℃,总压0.10～0.15MPa.该法原料来源广泛,工艺简单,成本低,产品质量好并且绿色环保,具有良好的工业前景.
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| 关 键 词： | 乙醛酸 对羟基扁桃酸 对羟基苯乙酸 |
Synthesis of 4-hydroxyphenyl acetic acid |
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| LI Sheng-hui
,
XIA Jing
,
ZHANG Li-long
,
WANG Yao-xuan.Synthesis of 4-hydroxyphenyl acetic acid[J].Journal of Hebei University (Natural Science Edition),2012,32(3):265-268. |
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| Authors: | LI Sheng-hui XIA Jing ZHANG Li-long WANG Yao-xuan |
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| Institution: | (College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China) |
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| Abstract: | The target compound was obtained by condensation and reduction from phenol,50% glyoxylic acid,and sodium bisulfite.The mass fraction and purity of 4-hydroxyphenyl acetic acid,determined by HPLC,were 97.5% and 99.65% respectively.The yield of sodium-4-hydroxyphenyl acetic acid reached 85% when the molar ratio of glyoxylic acid,phenol and sodium hydroxide was 1∶1.5∶2.5.The reductive reaction was performed at 100 ℃,under the pressure of 0.10-0.15 MPa,at 1∶1.1 molar ratios of sodium-4-hydroxymandalate monohydrate to sodium bisulfite.This method has a better industrial prospects by its extensive raw material,simple process,lower cost,better product quality and environmental protection. |
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| Keywords: | glyoxylic acid 4-hydroxymandelic acid 4-hydroxyphenyl acetic acid |
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