Biodistribution of fullerene derivative C60(OH)x(O)y |
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Authors: | Qingnuan Li Yan Xiu Xiaodong Zhang Ruili Liu Qianqian Du Xiaoguang Sun Shaoliang Chen Wenxin Li |
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Institution: | (1) Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, 201800 Shanghai, China;(2) Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 200032 Shanghai, China |
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Abstract: | The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand
the biodistribution of C60 derivatives as drugs or drug carriers, a simple water-soluble derivative C60(OH)x(O)y was labeled with99mTc. A γ-counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism
of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly
by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow
from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some
difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study
is needed to find out to what extent the C60 itself determines the biodistribution of derivatives. |
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Keywords: | C60(OH)x(O)y 99mTc-labeling activity test SPECT imaging biodistribution |
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