放射性碘(131I)联合小剂量甲巯咪唑治疗甲亢性心脏病临床价值分析

目的 探讨放射性碘(131I)联合小剂量甲巯咪唑治疗甲亢性心脏病的临床价值.方法 从甲亢性心脏病患者中随机抽选出78例作为研究对象,按照治疗方案将所有患者分成对照组与观察组(各39例),分别给予两组患者小剂量甲巯咪唑治疗与放射性碘、小剂量甲巯咪唑联合治疗,比较两种治疗方案患者心电图指标、甲状腺功能以及临床疗效、不良反应发生率之间的差异.结果 观察组的左室舒张末内径(LVEDD)、右室收缩内末径(LVESD)、左室射血分数(LVEF)水平改善情况好于对照组;观察组的甲状腺功能提高程度大于对照组;观察组的治疗总有效率(92.31%)较对照组(71.79%)明显升高;观察组的不良反应发生率(2.56%)较对照组(15.38%)明显降低 (P<0.05).结论 放射性碘(131I)联合小剂量甲巯咪唑疗法可有效改善患者的心电图指标与机体甲状腺功能,患者临床治疗效率明显提高,不良反应发生率明显降低.

Clinical Values of Radioactive Iodine (131I) Combined with Low Dose of Methimazole for the Treatment of Hyperthyroid Heart Disease

Objective To investigate the clinical value of radioactive iodine (131I) combined with low dose methimazole in the treatment of hyperthyroid heart disease.Method A total of 78 patients with hyperthyroid heart disease were randomly selected as the objects.All the patients were divided into control group (39 cases) and observation group (39 cases) according to the different treatment regimens.Patients in the control group and the observation group were respectively given low dose of methimazole and low dose methimazole combined with radioactive iodine therapy.The ultrasound and ECG indicators,thyroid function,clinical efficacy,and the incidence of adverse reactions were compared between the two groups after the treatment with the two different therapies.Results LVEDD,LVESD and LVEF in the observation group were significantly improved compared with those in the control group.The total effective rate (92.31%) in the observation group was significantly higher than that in the control group (71.79%);the incidence of adverse reactions in the observation group (2.56%) was significantly lower than that in the control group (15.38%)(P<0.05).Conclusion The therapy of low dose of methimazole combined with radioactive iodine can not only improve the electrocardiogram and the thyroid function,but also improve the clinical efficiency in patients with hyperthyroid heart disease and reduce the incidence of adverse reaction significantly,indicating that the therapy has a very high clinical value.