| 钙阻断剂与肿瘤治疗 |
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| 引用本文： | 何农高.钙阻断剂与肿瘤治疗[J].西华师范大学学报(哲学社会科学版),1991,12(4):333-335. |
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| 作者姓名： | 何农高 |
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| 作者单位： | 四川师范学院生物系 |
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| 摘 要： | 抗药性是肿瘤化疗的最大障碍之一,具抗药性的肿瘤细胞药物外排功能很强,而钙阻断剂能抑制抗癌药物从抗药性肿癌细胞排出,导致细胞抗药性减弱,可用于肿囊化疗,有潜在的临床应用价值,但有副作用。故应寻求毒副作用小类似钙阻断剂的其他修饰物以促进肿癌化疗。
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| 关 键 词： | 肿瘤 治疗学 钙通道阻滞剂 抗药性 |
TREATMENT OF TUMORS WITH CALCIUM ANTAGONISTS |
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| He Nonggao.TREATMENT OF TUMORS WITH CALCIUM ANTAGONISTS[J].Journal of China West Normal University:Natural Science Edition,1991,12(4):333-335. |
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| Authors: | He Nonggao |
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| Institution: | Biology Department |
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| Abstract: | Drug-resistance is one of the largest obstacles to the cancer chemotherapy. Drug-resistant tumor cell possesses an enhanced drug-efflux function. Calcium antagonists inhibit the efflux of anticancer drugs from resistant tumor cells, thus resulting in a reduction of drug resistance. Chemotherapy with calcium.antagonists has potential usefulness clinically; however, the drugs induce side effects. The research for better drugs with fewer side effects will be rewarding. |
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| Keywords: | tumor treatment drug resistance calcium antagonists |
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