Development of fully 3D image reconstruction techniques for pinhole SPECT imaging |
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Authors: | XueZhu Zhang YuJin Qi |
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Institution: | (1) Department of Radiology, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104, USA;(2) School of Medicine, Duke University Medical Center, Durham, NC 27710, USA;(3) Department of Radiology, Duke University Medical Center, DUMC-3949, Durham, NC 27710, USA |
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Abstract: | The purpose of this study was to develop fully 3D image reconstruction techniques for pinhole SPECT imaging with our Micro-SPECT
system. Our studies involve in the derivation of projection operators, analysis of the sampling characteristics of pinhole
SPECT imaging in Radon space, development of effective geometric calibration method for system misalignment, and 3D image
reconstruction development and implementation with quantitative degrading compensation for pinhole SPECT with both circular
and helical scan. The performances of pinhole SPECT imaging were evaluated using computer simulations and experiments with
the Ultra-Micro Hot-Spot phantom, Ultra-Micro Defrise phantom and small-animal imaging. The results from the computer simulations
and phantom imaging experiments indicate that the statistically-based iterative algorithms with quantitative compensation
provide overall image quality improvement, and the system resolution is significantly recovered for quantitative imaging.
The helical pinhole SPECT improves the axial field-of-view (FOV) as compared with the standard pinhole SPECT with circular-orbit
scan. The mouse bone imaging experiment shows that the helical pinhole SPECT imaging also provides decent high-resolution
whole-body small animal imaging. In conclusion, we have successfully developed a set of valid fully 3D image reconstruction
techniques for single-pinhole SPECT imaging. These techniques can be easily extended to multi-pinhole SPECT imaging. |
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Keywords: | pinhole SPECT fully 3D image reconstruction sufficient sampling quantitative compensation geometric calibration computer simulation |
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