Role of Tip60 tumor suppressor in DNA repair pathway |
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Authors: | ZhiJian Liu YingLi Sun |
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Institution: | (1) Department of Toxicology, University of Mainz, D-55131 Mainz, Germany |
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Abstract: | To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms.
The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation
which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated
that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the
current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage. |
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Keywords: | Tip60 ATM MRN histone methylation DNA damage DNA repair |
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