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The importance of HLA-G expression in embryos,trophoblast cells,and embryonic stem cells |
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| Authors: | Roberta?Rizzo,Martine?Vercammen,Hilde?van de?Velde,Peter?A.?Horn,Vera?Rebmann author-information" > author-information__contact u-icon-before" > mailto:vera.rebmann@uk-essen.de" title=" vera.rebmann@uk-essen.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara, Ferrara, Italy;(2) Department of Hematology, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(3) Centre for Reproductive Medicine, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(4) Department of Reproduction and Genetics, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(5) Institute for Transfusion Medicine, University Hospital of Essen, Virchowstr. 179, 45122 Essen, Germany; |
| Abstract: | The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every pregnancy. It differs from classical HLA class I molecules by the low degree of allelic variants and the high diversity of protein structures. HLA-G is reported to be a tolerogenic molecule that acts on cells of both innate and adaptive immunity. At the maternal–fetal interface HLA-G seems to be responsible largely for the reprogramming of local maternal immune response. This review will focus on the HLA-G gene expression profile in pregnancy, in preimplantation embryos, and in human embryonic stem cells with emphasis on the structural diversity of the HLA-G protein and its potential functional and diagnostic implications. |
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