| 放线菌Z802031次级代谢产物放线菌素X2的研究 |
| |
| 引用本文： | 孙肇暘,张明明,秦德华,杨秀萍.放线菌Z802031次级代谢产物放线菌素X2的研究[J].首都师范大学学报(自然科学版),2011,32(3):18-22. |
| |
| 作者姓名： | 孙肇暘 张明明 秦德华 杨秀萍 |
| |
| 作者单位： | 1. 首都师范大学,北京,100048
2. 中国医学科学院医药生物技术研究所,北京,100050 |
| |
| 摘 要： | 从西藏卡拉山地区土样分离到的一株放线菌Z802031能够产生具有抗菌、抑制肿瘤细胞生长的次级代谢产物.对其产生的抗肿瘤活性物质进行发酵、提取、分离,得到五个组分,经MTT法检测有两个组分具有显著的抗肿瘤活性,并对其中之一进行分离纯化,并获得单体,对该单体进行质谱、核磁共振、红外、紫外等波谱分析、鉴别,结果表明,Z802...
|
| 关 键 词： | 放线菌素X2 放线菌 抗肿瘤 抗菌 波谱分析 |
Actinomycin X2 as a Secondary Metabolite Produced by Actinomycete Z802031 |
| |
| Sun Zhaoyang,Zhang Mingming,Qin Dehua,Yang Xiuping.Actinomycin X2 as a Secondary Metabolite Produced by Actinomycete Z802031[J].Journal of Capital Normal University(Natural Science Edition),2011,32(3):18-22. |
| |
| Authors: | Sun Zhaoyang Zhang Mingming Qin Dehua Yang Xiuping |
| |
| Institution: | Sun Zhaoyang1Zhang Mingming1Qin Dehua2Yang Xiuping1,*(Capital Normal University,Beijing100048,Institute of Medicinal Biotechnology CAMS,Beijing100050) |
| |
| Abstract: | Actinomycete Z802031 which isolated from Kala mount in Tibet could produce metabolites of antibacterial and antitumor activity.By fermenting,extracting and severing,five components were separated from the fermentation of Z802031 and two of them have remarkable tumor cell growth inhibiting effect detected by MTT assay.The major one was further isolated and purified as monomer and identified as Actinomycin X2 on the basis of spectroscopic analysis,mainly including MS,NMR,IR and UV. |
| |
| Keywords: | actinomycin X2 actinomycete antibacterial antitumor spectroscopic analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
