Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes |
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| Authors: | N Sagata M Oskarsson T Copeland J Brumbaugh G F Vande Woude |
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| Institution: | Bionetics Research Inc., National Cancer Institute, Frederick, Maryland 21701. |
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| Abstract: | The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division. |
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