| Expression of TGF-β2 in LECs of Age-Related Nuclear, Cortex Cataract and the Relationship among TGF-β2, Proliferation,Apoptosis and Transdifferentiation |
| |
| 引用本文： | YE Lin~,CAI Xiaojun~,ZHANG Baifang~ ,LUO Hong~,Deng Ping~ . Ophthalmology Department,Zhongnan Hospital,Wuhan University,Wuhan ,Hubei,China, . Medical School,Wuhan University,Wuhan ,Hubei,China.Expression of TGF-β2 in LECs of Age-Related Nuclear, Cortex Cataract and the Relationship among TGF-β2, Proliferation,Apoptosis and Transdifferentiation[J].武汉大学学报：自然科学英文版,2006,11(3):756-760. |
| |
| 作者姓名： | YE Lin~ CAI Xiaojun~ ZHANG Baifang~ LUO Hong~ Deng Ping~ . Ophthalmology |
| |
| 作者单位： | YE Lin~1，CAI Xiaojun~1，ZHANG Baifang~ 2，LUO Hong~1，Deng Ping~1 1. Ophthalmology Department，Zhongnan Hospital，Wuhan University，Wuhan 430071，Hubei，China; 2. Medical School，Wuhan University，Wuhan 430071，Hubei，China |
| |
| 基金项目： | Supported by the Natural Science Foundation of Hubei Province （2000-J059） |
| |
| 摘 要： | 0 IntroductionAsgue-br-eclaaptseudl acrat acraatcatr ianctc l,ud aems ocnogrte xwh,incuhcl,e acro ratnexdcataract and nuclear cataract are more i mportant .Cortex cataract is different from nuclear cataract inoccurring,developing and clinic display,evenin his-tology. The pathogenesis of age-related cataract hasnot been perfectly described.But it has been verifiedthat thereis alayer oflens epithelial cells (LECs) un-der vertebrates’lens anterior capsule, which is i m-portant in maintaining t…
|
| 关 键 词： | 白内障 皮质 TGF-β2 PCNA 细胞核抗原 |
| 文章编号： | 1007-1202（2006）03-0756-05 |
| 收稿时间： | 2005-04-12 |
Expression of TGF-β2 in LECs of age-related nuclear, cortex cataract and the relationship among TGF-β2, proliferation, apoptosis and transdifferentiation |
| |
| Ye Lin,Cai Xiaojun,Zhang Baifang,Luo Hong,Deng Ping.Expression of TGF-β2 in LECs of age-related nuclear, cortex cataract and the relationship among TGF-β2, proliferation, apoptosis and transdifferentiation[J].Wuhan University Journal of Natural Sciences,2006,11(3):756-760. |
| |
| Authors: | Ye Lin Cai Xiaojun Zhang Baifang Luo Hong Deng Ping |
| |
| Institution: | (1) Ophthalmology Department, Zhongnan Hospital, Wuhan University, 430071 Wuhan, Hubei, China;(2) Medical School, Wuhan University, 430071 Wuhan, Hubei, China |
| |
| Abstract: | To detect the pathogenesis of age-related cataract, we analyzed the expression of TGF-β2 mRNA, proliferation cell nuclear antigen (PCNA), Bcl-2/Bax, fibronection (FN), vimentin protein and the density of lens epithelial
cells(LECs) of nuclear cataract, cortex cataract and normal LECs. Results showed that the expression level of TGF-β2, mRNA, FN and vimentin protein was higher in LECs of cortex cataract than that of nuclear cataract and normal lens. But the
level of Bcl-2/Bax and PCNA was on the contrary. The density of LECs was (4250.63±275.05)/mm2 in cortex cataract. It was (5438.40±262.30)/mm2 in nuclear cataract, and (5368.63±211.07)/mm2 in normal LECs resepectively. There was significant difference between cortex and nuclear cataract (p<0.05). These suggested that TGF-β2 might take an important part in the process of age-related cataract. Age-related nuclear cataract was related to the proliferation
LECs. While cortex cataract was related to the apoptosis and transdifferentiation of LECs.
Foundation item: Supported by the Natural Science Foundation of Hubei Province (2000-J059)
Biography: YE Lin(1973-), female, Ph. D. candidate, research direction: pathogenesis of cataract. |
| |
| Keywords: | TGF-β 2 PCNA Bcl-2/Bax FN vimentin cataract cortex nuclear |
| 本文献已被 CNKI SpringerLink 等数据库收录！ |
|
