Benzamide potentiation of behavioral apomorphine-induced effects; mechanism involved |
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Authors: | F Piriou J Y Petit L Welin |
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Institution: | (1) Laboratoire de Pharmacodynamie, U.E.R. des Sciences Pharmaceutiques, 1, rue Gaston Veil, B.P. 1024, F-44035 Nantes, France |
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Abstract: | Summary A new N-pyridinyl benzamide was found to potentiate strongly the effects of apomorphine on the motility of reserpinized mice and on circling behavior. Since dopaminergic agonist activity could not account for this potentiation, involvement of-adrenergic agonist activity provided the only consistent explanation.Acknowledgments. We wish to thank Mr A. Decoodt for his excellent technical assistance and the Laboratoire de Chimie Therapeutique (Prof. Le Baut), Université de Nantes, for providing samples of N-PCB. |
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Keywords: | Apomorphine-induced behavior N-pyridinyl benzamide -adrenergic agonists" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-adrenergic agonists |
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