| 高血压病痰瘀证血栓前状态分子标志物变化及意义 |
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| 引用本文： | 金伟,哈木拉提·吾甫尔,沙吉旦·阿不都热衣木,热娜古丽·艾则孜,林雪.高血压病痰瘀证血栓前状态分子标志物变化及意义[J].科技导报(北京),2009,27(9). |
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| 作者姓名： | 金伟 哈木拉提·吾甫尔 沙吉旦·阿不都热衣木 热娜古丽·艾则孜 林雪 |
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| 作者单位： | 金伟,JIN Wei(新疆医科大学中医学院,乌鲁木齐 830000;新疆乌鲁木齐市中医医院,乌鲁木齐 830000);哈木拉提·吾甫尔,热娜古丽·艾则孜,UPUR Halmurat,AIZEZI Renaguli(新疆医科大学维吾尔医药系,乌鲁木齐,830000);沙吉旦·阿不都热衣木,ABUDOUREYIMU Shajidan(新疆医科大学第一附属医院,乌鲁木齐,830000);林雷,LIN Xue(新疆医科大学附属中医医院,乌鲁木齐,830000)
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| 基金项目： | 国家杰出青年科学基金 |
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| 摘 要： | 探讨高血压病痰瘀证患者血栓前状态分子标志物变化和意义.分别采用流式细胞仪、ELISA法、CLAUSS法等,检测高血压病痰瘀证组、非痰瘀证组和正常对照组血小板膜表面糖蛋白CD41和CD62P、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制剂(PAI-1)以及凝血4项指标:血浆凝血酶原时间(PT)、纤维蛋白原(Fib)、凝血酶时间(TT)和活化部分凝血活酶时间(APTT).结果显示:①与对照组比较,高血压病痰瘀证组CD41表达、TT无统计学意义(P>0.05),CD62P表达显著升高(P<0.01),t-PA含量下降(P<0.05),PAI-1含量显著升高(P<0.01 ),Fib含量显著升高(P<0.01),PT、APTT显著缩短(P<0.01);非痰瘀证组CD62P表达升高(P<0.05),t-PA含量下降(P<0.05).Fib含量显著升高(P<0.01),APTT显著缩短(P<0.01),而CD41、PAI-1、PT、TT无统计学意义(P>0.05).②与非痰瘀证组对比,痰瘀证组CD62P表达显著升高{P<0.01),而CD41表达,t-PA、PAI-1含量,PT、Fib、TT和APTT则无统计学意义(P>0.05).由此得出结论:高血压病痰瘀证和非痰瘀证均存在不同程度的血栓前状态,而且痰瘀证较非痰瘀证更为明显,并以CD62P、t-PA、PAI-1、PT、Fib、APTT等的改变为主.
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| 关 键 词： | 高血压 痰瘀证:血栓前状态 |
Effects of Molecular Markers of Prethrombotic State on the Phlegm-stasis Syndrome of Hypertension Disease |
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| JIN Wei,UPUR Halmurat,ABUDOUREYIMU Shajidan,AIZEZI Renaguli,LIN Xue .College of Chinese Medicine,Xinjiang Medical University,Urumqi ,China .Urumqi Traditional Chinese Medicine Hospital,Xinjiang,China.Effects of Molecular Markers of Prethrombotic State on the Phlegm-stasis Syndrome of Hypertension Disease[J].Science & Technology Review,2009,27(9). |
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| Authors: | JIN Wei UPUR Halmurat ABUDOUREYIMU Shajidan AIZEZI Renaguli LIN Xue College of Chinese Medicine Xinjiang Medical University Urumqi China Urumqi Traditional Chinese Medicine Hospital Xinjiang China |
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| Institution: | JIN Wei1,2,UPUR Halmurat3,ABUDOUREYIMU Shajidan4,AIZEZI Renaguli3,LIN Xue5 1.College of Chinese Medicine,Xinjiang Medical University,Urumqi 830000,China 2.Urumqi Traditional Chinese Medicine Hospital,Xinjiang,China 3.Department of Uighur Medicine,China4.The First Affiliated Hospital of Xinjiang Medical University,China 5.Department of Hypertension,Chinese Hospital of Traditional Medicine,China |
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| Abstract: | |
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| Keywords: | hypertension phlegm -stasis syndrome prethrombotic state |
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