| 甘氨酸和多粘菌素B合用在体内对内毒素致热性的拮抗作用 |
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| 引用本文： | 戚仁斌,陆大祥,王华东,王彦平,颜亮,付咏梅,李楚杰.甘氨酸和多粘菌素B合用在体内对内毒素致热性的拮抗作用[J].暨南大学学报,2001,22(6):10-13. |
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| 作者姓名： | 戚仁斌 陆大祥 王华东 王彦平 颜亮 付咏梅 李楚杰 |
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| 作者单位： | 暨南大学医学院病理生理学教研室, |
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| 基金项目： | 广东省“五个一科教兴医工程”重点科研项目基金资助 |
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| 摘 要： | 目的 :探讨甘氨酸和多粘菌素B在体内对内毒素致热性的拮抗作用。方法 :以内毒素诱导家兔发热 ,实验组预先单独或联合给予相应剂量的甘氨酸和多粘菌素B ,测量各组家兔的直肠体温。结果 :用半剂量的甘氨酸 /多粘菌素B预处理对内毒素致热性有明显的拮抗作用 (P <0 0 5 ) ,并且其效果与预先给予全剂量多粘菌素B者无显著性差异 (P >0 0 5 )。结论 :在家兔体内合用甘氨酸和多粘菌素B预处理可以有效地拮抗内毒素引起的发热 ,并且可以降低单一药物的使用剂量。
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| 关 键 词： | 甘氨酸 多粘菌素B 内毒素 拮抗剂 致热性 疾病防治 药理学 |
| 文章编号： | 1000-9965(2001)06-0010-04 |
Role of antagonism of glycine and polymyxine B in pyrogenicity of endotoxin in vivo |
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| QI Ren-bin,LU Da-xiang,WANG Hua-dong,WANG Yan-ping,YAN Liang,FU Yong-mei,LI Chu-jie.Role of antagonism of glycine and polymyxine B in pyrogenicity of endotoxin in vivo[J].Journal of Jinan University(Natural Science & Medicine Edition),2001,22(6):10-13. |
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| Authors: | QI Ren-bin LU Da-xiang WANG Hua-dong WANG Yan-ping YAN Liang FU Yong-mei LI Chu-jie |
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| Abstract: | Aim: To explore the role of antagonism of glycine and polymyxine B(Gly/PMB) in pyrogenicity of endotoxin(ET) in vivo.Methods: Changes of rectal temperature were observed in feverous rabbits induced by endotoxin. The experiment group were pre-treated by half-dose Gly/PMB in vivo.Results: Pre-treatment of half-dose Gly/PMB significantly antagonized pyrogenicity of ET in vivo (P<0.05). The role was the same as the total dose of PMB used (P>0.05).Conclusion: Pre-treatment of Gly/PMB could inhibit febrile response induced by ET in vivo and decrease dosage of medicine. |
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| Keywords: | glycine polymyxin B endotoxin antagonist |
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