| 聚乳酸-聚扁桃酸共聚物的合成与表征 |
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| 引用本文： | 于美玲,蒋琳,肖臻,周江峰,袁明龙.聚乳酸-聚扁桃酸共聚物的合成与表征[J].云南民族大学学报(自然科学版),2014,23(5):320-325. |
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| 作者姓名： | 于美玲 蒋琳 肖臻 周江峰 袁明龙 |
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| 作者单位： | 云南民族大学云南省生物高分子功能材料工程技术研究中心,云南昆明,650500 |
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| 摘 要： | 合成乳酸OCA和扁桃酸OCA单体,用DMAP引发乳酸OCA和扁桃酸OCA开环共聚合成可生物降解的聚乳酸-聚扁桃酸共聚物,通过调节聚合共聚单体的比例,可得到分子量从3 62011 800 g/mol不等的共聚物,实现了分子量可控的目的.使用1H NMR、GPC、DSC、TEM、XRD等手段对共聚物进行了表征,所得共聚物的热力学性能、降解性能等均得到改善.并对轮状病毒进行负载制备成载药微球,对其降解行为进行研究,为药物控制释放提供一类新的载体材料.
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| 关 键 词： | 乳酸OCA 扁桃酸OCA 聚乳酸-聚扁桃酸共聚物 药体载体 |
Synthesis and characterization of poly (lactic acid-co-mandelic acid) copolymers |
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| YU Mei-ling,JIANG Lin,XIAO Zhen,ZHOU Jiang-feng,YUAN Ming-long.Synthesis and characterization of poly (lactic acid-co-mandelic acid) copolymers[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2014,23(5):320-325. |
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| Authors: | YU Mei-ling JIANG Lin XIAO Zhen ZHOU Jiang-feng YUAN Ming-long |
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| Institution: | YU Mei-ling;JIANG Lin;XIAO Zhen;ZHOU Jiang-feng;YUAN Ming-long;Engineering Research Center of Biopolymer Functional Materials of Yunnan,Yunnan Minzu University; |
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| Abstract: | Copolymers of poly( lactic acid- co- mandelic acid) were synthesized by ring- opening polymerization of lactic acid OCA and mandelic acid OCA monomer with DMAP as a catalyst. The molecular weight can be controlled and adjusted by the ratio of monomers in the process of polymerization,and copolymers with a molecule weight of 3 620—11 800 g /mol have been obtained. The structures and properties of the copolymers were characterized with1 H NMR,GPC,DSC,TEM and XRD,and the thermodynamic performance and degradation performance of the copolymers were improved. We have also prepared the microsphere which loaded rotavirus,and studied its degradation behavior. A new drug carrier material for drug controlled release has been prepared in this way. |
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| Keywords: | L-lactic acid OCA L-mandelic acid OCA poly (lactic acid-co-mandelic acid) copolymers drug carrier |
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