| Advances in studies on hepatic stem cells |
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| 作者姓名： | HE Zuping TANG Yuefeng LIU Yabing FENG Meifu |
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| 作者单位： | State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China,State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China,State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China,State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China |
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| 基金项目： | Supported by National 863 Program (Grant No. 2001AA216051) and Natural Science Foundation of Beijing (Grant No. 7022023) |
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| 摘 要： | The question whether hepatic stem cells exist or not has been debated for several decades. Current researches confirm that there are hepatic stem cells in the liver. Oval cells, putative bipotential hepatic stem cells, are probably located within canals of Hering, portal tracts or branches of biliary trees. Bone marrow is a potential source of oval cells, indicating that there exists a close relationship between liver and hematopoiesis in adulthood. Hepatic stem cells are able to proliferate in vitro and can be induced to differentiate into hepatocytes. This will provide a promising approach of cell transplantation, tissue engineering and gene therapy for liver diseases. In this review, the evidence of their presence, origin, identification, proliferation in vitro, differentiation by induction, application prospects of hepatic stem cells and future directions for the field are discussed.
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| 关 键 词： | hepatic stem cells origin identification proliferation in vitro differentiation by induction cl |
Advances in studies on hepatic stem cells |
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| HE Zuping,TANG Yuefeng,LIU Yabing,FENG Meifu.Advances in studies on hepatic stem cells[J].Progress in Natural Science,2003,13(3):166-172. |
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| Authors: | HE Zuping TANG Yuefeng LIU Yabing FENG Meifu |
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| Institution: | State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | The question whether hepatic stem cells exist or not has been debated for several decades. Current researches confirm that there are hepatic stem cells in the liver. Oval cells, putative bipotential hepatic stem cells, are probably located within canals of Hering, portal tracts or branches of biliary trees. Bone marrow is a potential source of oval cells, indicating that there exists a close relationship between liver and hematopoiesis in adulthood. Hepatic stem cells are able to proliferate in vitro and can be induced to differentiate into hepatocytes. This will provide a promising approach of cell transplantation, tissue engineering and gene therapy for liver diseases. In this review, the evidence of their presence, origin, identification, proliferation in vitro, differentiation by induction, application prospects of hepatic stem cells and future directions for the field are discussed. |
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| Keywords: | hepatic stem cells origin identification proliferation in vitro differentiation by induction cl |
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