| 肌醇磷脂降解物在大鼠输精管平滑肌收缩中的作用 |
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| 引用本文： | 宋世一,马宏.肌醇磷脂降解物在大鼠输精管平滑肌收缩中的作用[J].沈阳师范大学学报(自然科学版),2000,18(2):56-59. |
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| 作者姓名： | 宋世一 马宏 |
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| 作者单位： | 1. 沈阳师范学院生物系，辽宁沈阳 110034
2. 沈阳医学院，辽宁沈阳 110031 |
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| 摘 要： | 探讨肌醇磷脂代谢及其降解产物在大鼠输精管平滑肌收缩中的作用．用32P对输精管平滑肌进行标记，用薄层层析进行脂类分类，用放射自显影方法对磷脂进行定量研究，结果表明去甲肾上腺素能促进大鼠输精管平滑肌PI、PC、PA的代谢，PKC的大分子抑制剂和氯丙嗪不完全地抑制其代谢，Ca2+对上述反应有加速作用．本文提示去甲肾上腺素通过促进PI的代谢激活PKC，进而引起平滑肌的收缩，存在于输精管平滑肌中的PKC大分子蛋白抑制剂起着重要的调节作用．
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| 关 键 词： | 肌醇磷脂 输精管 平滑肌 蛋白激酶C抑制剂 |
| 文章编号： | 1008-374X(2000)02-0056-04 |
| 修稿时间： | 1999年9月21日 |
The Roles of metabolites of phosphoinoside breakdown in the Contraction of Smooth muscle in Vas Deferens |
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| Song Shi-yi,Ma Hong.The Roles of metabolites of phosphoinoside breakdown in the Contraction of Smooth muscle in Vas Deferens[J].Journal of Shenyang Normal University: Nat Sci Ed,2000,18(2):56-59. |
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| Authors: | Song Shi-yi Ma Hong |
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| Abstract: | Study the role of phosphoinoside breakdown and its products in the contraction of smooth muscle in rat vas deferens. 32 P-labelling of smooth muscle in vas deferens lipid analysis by t.l.c., quantitive phospholipid analysis by auto radiography. Noradrenlin can accelerate the breakdown of PI, PC and PA in smooth muscle in rat vas deferens. The macromole_cular in_hibitor and chloropromazine can Supress the breakdowns incompeletely, and the Ca 2 can accelerate the above reaction. Noradrenlin can activiate PKC by accelerate the PI breakdown, and induce to the contraction of smooth muscle. the macromolecular inhibitor of PKC located in smooth muscle in vas deferens have an important regulation role. |
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| Keywords: | phosphoinoside deferens smooth muscle PKC inhibitor |
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