Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis |
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| Authors: | H. Kitamura S. Okamoto Y. Shimamoto M. Morimatsu A. Terao M. Saito |
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| Affiliation: | (1) Laboratory of Biochemistry, Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo 060 (Japan), Fax +81 11 757 0703, e-mail: saito@vetmed.hokudai.ac.jp, JP;(2) Laboratory of Toxicology, Department of Environmental Veterinary Medical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo (Japan), JP |
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| Abstract: | Centrally given interleukin (IL)-1 is known to induce a rapid rises in blood IL-6. To extend this and to examine the mechanism by which this occurs, the effects of intracerebroventricular (icv) injection of human recombinant IL-1β on mRNA expression of IL-6 and tumour necrosis factor (TNF) in the spleen and liver were examined in rats. Icv injection of IL-1 produced a rapid rise of the tissue mRNA levels of IL-6 and TNF in both organs, prior to and/or in parallel with an increase in their serum levels. Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the IL-6 responses, while it had little influence on the TNF responses. The results suggest that brain IL-1 induces peripheral production of IL-6, but not of TNF, through autonomic nervous system activation. Received 27 October 1997; received after revision 15 December 1997; accepted 12 January 1998 |
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| Keywords: | . Interleukin-1 (IL-1) interleukin-6 (IL-6) tumour necrosis factor (TNF) autonomic nervous system cytokine. |
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