| 非水电位滴定法测定阿戈美拉汀工作对照品的含量 |
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| 引用本文： | 聂忠莉,王晓玲,李长生,唐雪树,陈小宁. 非水电位滴定法测定阿戈美拉汀工作对照品的含量[J]. 成都大学学报(自然科学版), 2012, 31(3): 221-223. DOI: 10.3969/j.issn.1004-5422.2012.03.007 |
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| 作者姓名： | 聂忠莉 王晓玲 李长生 唐雪树 陈小宁 |
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| 作者单位： | 1.成都大学生物产业学院,四川成都,610106;2.成都欣捷高新技术开发有限公司,四川成都,610041 |
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| 摘 要： | ：为建立非水电位滴定法测定阿戈美拉汀工作对照品的含量,采用非水电位滴定法以氯仿一醋酐（6：1）为溶剂,用高氯酸滴定液（O．1mol/L）进行滴定．实验结果表明,非水电位滴定法的方法的相对标准偏差（RSD）为0．1％（n=9）,平均回收率为99．8％,测定结果在统计学上无显著性差异．该方法简便快速,结果准确可靠．
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| 关 键 词： | 非水电位滴定法 阿戈美拉汀 工作对照品 含量 |
Content Determination of Agomelatine Working Standard by Non-aqueous Potentiometry Titration |
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| NIE Zhongli,WANG Xiaoling,LI Changsheng,TANG Xuefeng,CHEN Xiaoning. Content Determination of Agomelatine Working Standard by Non-aqueous Potentiometry Titration[J]. Journal of Chengdu University (Natural Science), 2012, 31(3): 221-223. DOI: 10.3969/j.issn.1004-5422.2012.03.007 |
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| Authors: | NIE Zhongli WANG Xiaoling LI Changsheng TANG Xuefeng CHEN Xiaoning |
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| Affiliation: | 1 .School of Biological Industry, Chengdu University, Chengdu 610106, China; 2. Chengdu Xinjie Hi-tech Development Co. Ltd., Chenglu 610041, China) |
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| Abstract: | To establish a non-aqueous potentiometry titration method for the content detenrrination of agome- latine working standard, trichloromethane and acetic anhydride（6： 1） were used as solvent for non-aqueous potentiomerry titration. 0.1 mol/L perchloric acid was used to titrate the content of agomelatine working standard. Results show that the conditions of non-aqueous potentiometry titration are the followings： the pre- cision RSD is 0.1% （n = 9）, the average recovery is 99.8 %. It is concluded that the outcome obtained by non-aqueous potentimetry titration method has no statistical difference. This method is simple and fast with accurate and countable results. |
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| Keywords: | non-aqueous potentiometry titration method agomelafine working standard content |
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