Splicing signals in the human hemoglobin genes at the sequence and folding levels |
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| Authors: | Wen Zhang Huazhen Xie Qing Li Lu Zhang Ciquan Liu |
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| Institution: | ZHANG Wen1,2,XIE Huazhen1,LI Qing2,ZHANG Lu2,LIU Ciquan1,3 1. Modern Biology Research Center,Yunnan University,Kunming 650091,Yunnan,China,2. Department of Cell Biology and Genetics,Kunming Medical College,Kunming 650031,3. Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223 |
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| Abstract: | Identification of the splice sites is a critical and tough issue in eukaryotic genome annotation. Here, a statistical study is introduced for detecting the splicing signals in the human hemoglobin (Hb) pre-mRNAs by using the approaches of regional pairwise alignment, splicing weight matrix scoring, and dynamic extended folding. First, the regional pairwise alignment results show that the coding regions of the human Hb genes are at a high level for both conservation and fluctuation. Second, the weighted matr... |
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| Keywords: | splice site regional pairwise alignment splicing weight matrix dynamic extended folding |
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