| 青蒿素在亚铁离子催化下的裂解产物-3-羟基脱氧青蒿素 |
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| 引用本文： | 李淑辉,乐征宇,高坡.青蒿素在亚铁离子催化下的裂解产物-3-羟基脱氧青蒿素[J].黑龙江大学自然科学学报,2006,23(2):253-256. |
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| 作者姓名： | 李淑辉 乐征宇 高坡 |
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| 作者单位： | 黑龙江大学,化学化工与材料学院,黑龙江,哈尔滨,150080 |
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| 基金项目： | 国家自然科学基金
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黑龙江大学校科研和教改项目 |
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| 摘 要： | 用硫酸亚铁引发青蒿素的自由基裂解反应,对主产物之一的3-羟基脱氧青蒿素进行了单晶培养和X射线的表征,运用环Puckering分析方法对结构中环的构象进行了半定量描述。其中六元环分别呈现微扭曲的椅式构象、严重扭曲的椅式构象及半椅式构象;五员环的构象呈信封式,为探索构效关系、开发新型抗疟药物提供了必要的理论依据。
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| 关 键 词： | 青蒿素 3-羟基脱氧青蒿素 晶体结构 Puckering分析 |
| 文章编号： | 1001-7011(2006)02-0253-04 |
| 修稿时间： | 2005年9月23日 |
The reaction product of QHS with ferrous ion-3-hydroxy deoxyartemisinin |
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| LI Shu-hui,YUE Zheng-yu,GAO Po.The reaction product of QHS with ferrous ion-3-hydroxy deoxyartemisinin[J].Journal of Natural Science of Heilongjiang University,2006,23(2):253-256. |
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| Authors: | LI Shu-hui YUE Zheng-yu GAO Po |
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| Abstract: | Artemisinin was reacted with ferrous sulphate to give free radical products.One of the two major products was characterized by single crystal X-ray diffraction.Here the rings configuration in the crystal structure is described clearly by semi-quantitative ring puckering analysis.The six-membered rings exhibit slightly distorted chair,extremely distorted chair and half-chair conformation respectively,and the five-membered ring exhibits an envelope conformation.The result may provide a support for research of structure-function relation and exploitation of new antimalarial drugs. |
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| Keywords: | artemisinin 3-hydroxy deoxyartemisinin crystal structure Puckering analysis |
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