| 凋亡基因Survivin在宫颈鳞癌中的表达及其相关性 |
| |
| 引用本文： | 李云,徐建平,黎清. 凋亡基因Survivin在宫颈鳞癌中的表达及其相关性[J]. 暨南大学学报(自然科学与医学版), 2009, 30(6) |
| |
| 作者姓名： | 李云 徐建平 黎清 |
| |
| 作者单位： | 暨南大学附属第一医院妇产科,广东,广州,510630;暨南大学附属第一医院妇产科,广东,广州,510630;暨南大学附属第一医院妇产科,广东,广州,510630 |
| |
| 摘 要： | 目的:探讨不同分期宫颈鳞癌组织中Survivin基因表达的特征及其临床意义.方法:应用免疫组化法(S-P法)及图像分析技术检测凋亡基因Survivin在38例宫颈鳞癌的表达情况.0期9例、Ⅰ b期10例、Ⅱa期7例、Ⅱb期7例、Ⅲa期5例,将0期及Ⅰ b期合并为早期,Ⅱa期～Ⅲa期合并为晚期.结果:在早期和晚期宫颈鳞癌组织中均有凋亡基因Survivin的阳性表达,但表达强度不同,早期宫颈鳞癌组织中Survivin PU值为(20.65±4.57),而晚期宫颈鳞癌组织中Survivin PU值为(24.94±5.64),两者比较有统计学差异(P<0.05).结论:Survivin基因在宫颈鳞癌组织中异常表达与宫颈鳞癌的发生及临床分期相关.
|
| 关 键 词： | Survivin基因 宫颈鳞状细胞癌 免疫组化 图像分析 |
Expression and correlation of apoptosis gene survivin in the different stages of cervical cancer |
| |
| LI Yun,XU Jian-ping,LI Qing. Expression and correlation of apoptosis gene survivin in the different stages of cervical cancer[J]. Journal of Jinan University(Natural Science & Medicine Edition), 2009, 30(6) |
| |
| Authors: | LI Yun XU Jian-ping LI Qing |
| |
| Abstract: | Aim :To investigate the expression and correlation of apoptosis gene survivin in the different stages of cervical cancer tissue. Methods: Immunohistochemical and image analysis study of survivin gene was performed in 38 cases of cervical cancer(9 cases of 0 stage, 10 cases of Ⅰ b stage, 7 cases of Ⅱ a stage, 7 cases of Ⅱb stage, 5 cases of Ⅲ a stage). Results: The positive expressions of survivin were in the both of early stage cervical cancer and advanced cervical cancer. Intensity of survivin expres-sions changes correlated to different stage of cervical cancer. The mean positive unit of survivin in the ear-ly stage cervical cancer was (20.65±4.57) and that of advanced cervical cancer was (24.94±5.64). Conclusion:Abnormal expression of survivin in cervical cancer is correlated with different clinical stages. |
| |
| Keywords: | Survivin gene cervical cancer immunohistochemistry image analysis |
| 本文献已被 万方数据 等数据库收录！ |
|
