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Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility |
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| Authors: | Wang Xiaosong Ria Massimiliano Kelmenson Peter M Eriksson Per Higgins David C Samnegård Ann Petros Christina Rollins Jarod Bennet Anna M Wiman Björn de Faire Ulf Wennberg Charlotte Olsson Per G Ishii Naoto Sugamura Kazuo Hamsten Anders Forsman-Semb Kristina Lagercrantz Jacob Paigen Beverly |
| Institution: | The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. xw@jax.org |
| Abstract: | Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P |
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