沙苑子对运动训练大鼠骨骼肌自由基代谢的影响

通过建立力竭跑台训练模型,测试大鼠骨骼肌组织超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性、谷胱甘肽过氧化物酶(GSH-Px)活性、丙二醛(MDA)含量和ATP酶活性,探讨沙苑子对力竭跑台训练大鼠骨骼肌组织自由基代谢、ATP酶活性和运动能力的影响.结果显示,与安静组比较,运动力竭组SOD、CAT和GSH-Px活性降低,MDA含量升高;沙苑子组大鼠骨骼肌组织活性显著高于对照组,MDA含量明显低于相应对照组(P<0.01);运动力竭组Na 、K -ATPase和Ca2 、Mg2 -ATPase活性与安静组比较降低,沙苑子组大鼠骨骼肌组织ATPase活性显著高于对照组.沙苑子可显著提高运动大鼠抗氧化的功能,提高运动大鼠骨骼肌组织ATPase活性,具有较强抗氧化能力,使大鼠运动能力有了明显提高.

Effect of astragalus complanatus on metabolism of free radicals in the skeletal muscles of training rats

The research was to measure SOD and CAT activity,GSH-Px activity,MDA amount and ATPase activity in the skeletal muscle tissues of the rats in the exhaustive exercise training.The effects of astragalus complanatus on metabolism of free radicals,ATPase activity in the skeletal muscles of the exhaustive exercise training rats and the exercising performance of the rats were discussed.The results show:(1) Compared with quiet group,SOD,CAT and GSH-Px activities of the exhaustive exercise training group decrease,whereas MDA amount increases.The skeletal muscles of the rats in astragalus complanatus group are much more active than those of the rats in compared group.MDA amount is obviously lower than that of compared group(P<0.01);(2) Compared with quiet group,the activities of Na ,K -ATPase and Ca2 ,Mg2 -ATPase decreases,whereas T-ATPase activity increases.ATPase in the skeletal muscles of the rats in astragalus complanatus group is prominently more active than that in compared group.Astragalus complanatus can greatly enhance antioxidant ability of the exercising rats and ATPase activity in the skeletal muscles of the rats.As a result,astragalus complanatus can improve the exercising performance of the rats greatly.